Archive for the ‘Science’ Category

The Monster Mash

November 17, 2018

Biotech is one of the very bright spots in our future.

Unlike robotics and artificial intelligence (AI), biotech is an area that doesn’t threaten human employment or automate warfare—instead, it holds vast promise for improving our quality of life.

Miniaturization, which has resulted in the manipulation of molecules and even atoms, bred the field of nanotech—together, biotech and nanotech are the conduit to a brave new world.

For biomedical applications, these technologies have been used to grow new limbs, which is a remarkable achievement.

A 2015 review article from the US National Institutes of Health shows how far biomedical research has developed.

The difference between the natural process of regeneration and the human-engineered one is the fact that nature has no scaffold—many animals are able to regenerate whole limbs, starfish are able to regenerate whole animals. In New York Harbor, 19th century oystermen used to chop up starfish, a hated oyster predator, and chuck the parcels back into the ocean—each fragment would then grow into a new starfish and raid the oyster beds.

The image above may well be the grossest I’ve ever posted, but if you are that way inclined, the excellent NIH review article provides quite a collection.

Biotech has also been used for many decades to make food additives. I was amazed to find out in the late 1970s that sodas contained very little or none of the fruit that name them—lemonade, for instance, sources all its citric acid from fungus—and the biotechnology behind making it was published in 1917!

In recent years, we’ve turned to making food in the lab. It will be some time before biotech synthesizes a juicy Angus steak, but there’s been a lot of work done on hamburgers—the basis behind it is cell culture, and the trick is to get cells to replicate to form tissue.

Maybe it’s worth taking an elevator tour of BIO 101: Plants have no organs, only tissues. Animals are organized (excuse the pun) differently—vertebrates have organs such as a heart, liver, or kidneys. When (if) you eat steak, or Thanksgiving turkey, you are eating muscle tissue, skin (epidermal and dermal tissue), and surrounding fatty tissue. Thanks for taking this course.

If we want to manufacture steak in the lab, it’s a complex proposition—even burgers are a challenge, particularly if we want to have the kind of taste humans look for. Don’t forget that in the lab, we’re building them bottom-up (cells to tissues), not top-down (grinding steak).

One of the strong arguments for making meat from biotech is less cruelty to animals. For the species we eat, life is cruel indeed—cows, pigs, chickens, particularly those raised in industrial agriculture, do not have a pleasant lot.

Pigs in horribly crowded conditions at Fir Tree pig farm, UK (Guardian newspaper, September 2018).

A recent article in the Guardian highlighted the dreadful conditions, including torture, to which farm animals in supposedly developed countries are held.

More lab meat, less industrial agriculture, less torture of farmed animals. The flip-side is that in evolutionary terms it is possible, perhaps even likely, that these species would today be extinct.

Pigs and chickens were domesticated over millennia with a single purpose—the pot. There’s no certainty, had this not been the case, that Sus scrofa domesticus would exist at all—the population would be confined to some wild specimens; I leave it to you, dear reader, to weigh the relative merits of the issue.

Now it has come to fish—in particular, bluefin stem cells are being used to culture tuna—the challenges are multiple, including texture and taste—wild tuna are top predators that eat squid, mackerel, and sardines.

A company called Finless Foods is busy trying to make tuna in the lab. They compete with wild capture, which makes sense, but also with fish farms. Tuna farms are only a couple of decades old, and the cycle of tuna has recently been closed, meaning that it is possible to go from broodstock to hatchery, and then from nursery to growout.

This kind of full cycle approach isn’t used right now—instead, juvenile tuna are captured and caged, then grown on a diet of live fish, usually sardines. This has an effect on  sardine stocks, but it is no different than the effect restored populations of wild bluefin would have.

One consequence of farming bluefin is the shortening of the life cycle—animals are raised until they reach market size and then harvested. A shorter life cycle, and a knowledge of the environmental conditions at the growout site, ensure that farmed tuna have significantly lower levels of mercury than wild blue fin.

In a Washington Post article, the company explains that one of its products, carp paste, would presently cost nineteen thousand dollars per pound. In tuna and salmon, the omega-three fatty acids come from microscopic algae that live in the ocean, and to-date, nothing can replace them. The nutrients that bioengineered tuna cells require to grow must also be sourced from nature—the origin can be tweaked, but a pound of nitrogen is a pound of nitrogen.

With fish farming becoming increasingly more sustainable, more effort needs to be placed on raising tuna rather than catching it, and on improving animal welfare—in the end, it’s unlikely that cell culture of bluefin will lead to a reduction of wild catch.

What it may do is expedite research on early life-stages, providing a better way to culture and source juveniles—that will make a major contribution to sustainability.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

I Saw You Coming

October 20, 2018

Much of our world revolves around data—a lot of data. I’m talking about petabytes, yottabytes and the like. Put simply, you could fit all the academic research libraries in the US into two petabytes.

What kind of data are we talking about? Everything, including consumer products, news, crime, and weather.

That begs two questions. Where does the data come from, and who pays for it?

The data origin—not its provision—varies: records stored by humans provide a good deal of it. You are for instance able to tap into two hundred million records of crime data for the US. The data you access costs you money, and is the result of millions of security-related filings, including arrests, sentences, and paroles.

A second major source of data are sensors. These can be weather station sensors for wind speed or air temperature, buoys at sea measuring wave height, or satellites sitting high above you as you read these words. You are yourself part of the sensor network—as you read, your cellphone informs the cloud about your latitude and longitude. From that sensed data, we know whether you are sitting (and we know exactly where), and what time it is—if you sit there long enough, we will know where you live, or where you work—in a matter of days we’ll know both.

It’s a simple matter to find out who you live with, based on your coincidence in time and space, and build a relationship tree. If you’re moving slowly as you read these words, we’ll know you’re walking or strolling. If you’re moving fast, we know you’re in a vehicle—discovering whether it’s a car, bus, or train is a trivial matter. We can cross your trajectory with a highway map—if your vehicle makes frequent stops, you’re on a bus—or maybe you’re a UPS driver (but do me a favor, don’t read while you drive). Sensors provide huge amounts of data because they’re measuring stuff all the time.

The final source of data are models—these models don’t sashay on the catwalk, they run on computers, often using those very same sensor outputs to make forecasts—here’s that weather thing again.

The second question is even easier to answer. Who pays for it?

You do. You really should have seen that coming.

As a taxpayer, you fund the justice system, the weather office, the health system, the education system… delete as applicable, depending on where you live—I dearly hope no deletion is required.

When I was in the US, I picked up the latest book by Michael Lewis, called The Fifth Risk. I picked it up in the usual fashion, by seeing it an an airport store and promptly buying it on Kindle.

Now, Michael Lewis has been a favorite for years, so (unusually) I’ll plug an(other) author in these pages. Lewis has had a go at US investment bankers, the sub-prime mortgage scandal, the whole austerity deal in Europe, and HFT—High Frequency Trading is another scandalously well-kept secret—and yes, Big Data is at the heart of it. Oh, and he’s had a few goes at the orang-u-bang.

In summary, it’s a good job Lewis is not a Saudi national, otherwise he’d be part of an erector set by now. As an aside, the only simple question I want answered: if Khashoggi died in a fist fight, as claimed today, where’s the body? I suppose I’m also curious about why he got into a fist fight with fifteen guys.

The Fifth Risk took me two days to read, and I was fascinated by a chapter called ‘All the President’s Data.’ I want you to read the book, particularly in the lead-up to the mid-terms, so I won’t be a spoiler.

I will, however, tell you that US federal agencies such as the department of agriculture, NOAA, USGS, and NASA, have to provide data to the public as part of their mission statement. They are obviously not in the business of making the most sophisticated viewing interfaces for the consumer market—these are often done by third parties, but the key point is that those parties would be unable to source data were it not for the fact that you have paid for it to be made public, and more importantly, accessible in a simple way.

As an example, if you’re a US taxpayer, you support Wind Guru. The business model for this wind and wave forecasting website is fascinating—not least because the site is based in the Czech Republic, a land-locked nation. Every surfer knows Wind Guru—what most don’t know is that it isn’t a guru at all, the gurus are the US National Weather Service (NWS), the US Geological Survey, and others. Wind Guru accesses models run by NWS (a part of NOAA) using a special toolset known as web services.

Many government agencies worldwide provide such services, and this has allowed the private sector to develop some really nice tools for public use. The problem is when the private sector lobbies the government to try and stop the agencies that run the models being able to do anything but supply data.

One of the current discussions revolves around AccuWeather, which charges for its services, and its alleged efforts to limit how NOAA presents its own data, acquired through sensor networks paid for by (you saw it coming) the US taxpayer.

At the forefront of all this excitement is an American lawyer called Barry Myers, who is at present the CEO of AccuWeather. The exciting bit is that in October 2017, Myers was picked by Trump to lead NOAA.

The confirmation hearing is holding this one up. If Myers is confirmed, it means that an operator in the private sector of the multi-million weather forecast business will be in charge of a government agency that collects twenty terabytes of data every day, much of it weather-related.

The line between public and private becomes thinner and grayer than an old man’s hair.

If the orangutan buffoonery get away with this one, the fox will be firmly placed in charge of the henhouse.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

Unchain my Heart

October 13, 2018

Mental illness, from depression to schizophrenia, is a curse on those who suffer from it, as well as on their family and friends. And the provision of adequate care to the unfortunate people who live with this suffering is the responsibility of society—period.

The world map of disability is striking, particularly if you look at those red areas, and by that I mean the right column on the scale—from yellow to hemoglobin.

Mental illness worldwide—this graphic was published in PLOS Medicine by Ferrari and co-workers in 2013, and represents the YLD (Years Living with Disability) rate per 100,000 people.

Huge parts of South America, much of Africa and the Mid-East, and all of the ex-USSR. The exceptions are India and China, although in these broad assessments data quality can vary substantially from country to country.

Some mental disabilities, of which depression is a prime example, show well-established links to suicide rates—although most depressive people don’t kill themselves, two-thirds of suicides are committed by folks suffering from depression.

A recent study published by the Centers for Disease Control found that, for the period 1999-2016, the suicide rate has increased in all US states except Nevada—in some cases, particularly midwestern states, the rate has increased by fifty percent on average.

Anyone who travels widely quickly understands that the world is a very heterogeneous mix—for instance, what qualifies as underage sex in Europe and North America is very different from what you see in SE Asia.

Westerners, particularly those riding a high horse, are mostly unaware that one hundred-fifty years ago, the age of consent in the United States was… ten. In fact, the history of consent laws is an article in and of itself—we’ll leave it for another day.

What was acceptable in the West a century ago is reasonable in the East today—we see it in human rights, and in animal welfare. And unfortunately, we see it in mental health.

Ghana, which is colored blue in the YLD map, has one psychiatrist for every 1.2 million people—this statistic sounds so incredible, I dug in further. For a country of twenty-eight million, there should be twenty-three (and a third) shrinks—apparently there are eighteen.

The World Health Organization—undoubtedly another agency that Trump believes does the devil’s work—has calculated that developing countries spend only 0.5% of their health budget on mental health.

A mentally ill man shackled to a table in Java, Indonesia. The year is 2018, the picture was taken this month (courtesy Human Rights Watch.)

Ghana, like many other countries, had a practice of shackling mental patients, as a means of restraining them from normal activity, but has now banned the use of chains.

The lack of government facilities led to the development of ‘prayer camps’, where mentally ill folks are regularly chained, despite the ban. One such camp was recently visited by the BBC—staff proudly displayed the new facilities—when the reporter entered the housing units, a row of cages were the principal item of furniture.

And in each cage, a patient.

The BBC correspondent decided to try a cage for himself—he was unable to stand upright.

The video of the BBC report is horrifying, the suffering of the mentally ill in Ghana and many other countries is disgraceful.

Humans everywhere share a common trait—we have an old mind from an old world. We react to what happens on our street, our town, our region, pretty much in that order. We react to what happened yesterday, last month, last year, or the last decade in a similar way.

We think local, and we think now. This is why we elect xenophobes and re-elect politicians who only last year did us harm.

That’s why a mentally ill person kept in chains in some African nation is irrelevant when compared to Kayne West and Princess Eugenie.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

Twice

August 18, 2018

A year ago I wrote in these pages about a little-known place in the southwest coast of Spain—it’s still a well-kept secret, relaxed and foreigner-free—go there, my friends, but never ever trip-advise it!

Doing things twice is important—whether it’s the second time you make love to someone, or re-reading a book. In fact, when it comes to books, how many you read twice may be more important than the overall count.

Travel is similar for me—if I love a spot, I’ll go there twice, three times, and then it’s time for a change—I could never have a holiday home.

It’s been an odd summer in Europe, and just as strange in places like Japan. California, and its progenitor, Iberia, have been torched while the Trump administration relaxes car pollution rules.

This past week, Andalucia was cool—I was going to write ‘surprisingly’, but it’s time to hold off adverbs when describing the weather—nothing about the climate is surprising, except the fact that people aren’t worried enough to say “We have to do something about this weather,” just as they might address a persistent cough or an engine malfunction.

Climate change is going to cost a fortune, but just about everyone thinks the bill will be laid at someone else’s door, so an average gas guzzle of twenty-five miles to the gallon is currently the gold standard for the US.

The coastal strip of Andalucia is a land of fish and fishermen. I was in restaurants where a two-page menu contained no more than ten meat dishes, of which most were tapas. One snack-bar promised albondigas como pelotas de tenis—meatballs the size of tennis balls, but fish is the real deal.

And the Spanish will pay for their fish, make no mistake. Small boiled shrimp, the famous gamba blanca, are for sale in the market at around five bucks a pound—the mark-up in restaurants is one thousand percent.

It’s been a good week—baby shrimp tortillitas washed down with Manzanilla, a most special sherry that comes exclusively from Sanlúcar, anchovies in vinegar, and mantis shrimp, a rare treat.

The mantis shrimp is an amazing animal—it belongs to an ancient order of crustaceans called Stomatopoda, so called because they have gills on their feet. The fossil record of the mantis goes back four hundred million years—the species I saw (and ate) has a fake pair of eyes on its telson (tail) which will fool predators into biting the wrong bit.

The eyes themselves are also astounding. As are other physiological traits.

In April 1998, an aggressive creature named Tyson smashed through the quarter-inch-thick glass wall of his cell. He was soon subdued by nervous attendants and moved to a more secure facility in Great Yarmouth. Unlike his heavyweight namesake, Tyson was only four inches long. But scientists have recently found that Tyson, like all his kin, can throw one of the fastest and most powerful punches in nature. He is a mantis shrimp.

Mantis shrimps are aggressive relatives of crabs and lobsters and prey upon other animals by crippling them with devastating jabs. Their secret weapons are a pair of hinged arms folded away under their head, which they can unfurl at incredible speeds.

The ‘spearer’ species have arms ending in a fiendish barbed spike that they use to impale soft-bodied prey like fish. But the larger ‘smasher’ species have arms ending in heavy clubs, and use them to deliver blows with the same force as a rifle bullet.

The cool weather made it possible to drink red wine—in southern Spain they like to serve it chilled, which is tantamount to lèse-majesté. I firmly sent back the ice buckets—the perfect way to assassinate a tempranillo—the tinto fino enjoyed by the wily priest of The India Road.

And what better food to see off a good bottle of Pesquera than ventresca, thinly sliced tuna belly, grilled medium-rare?

The tuna was aleta amarilla, or yellowfin—I was hoping for bluefin, and had planned a trip east of Cadiz to a town called Conil. The offshore area is home to the most ancient tuna traps in the world, the almadrabas, which date back to the times of the Iberian caliphate, and before that, to the Phoenicians.

The traps are laid to capture tuna migrating from the Atlantic to the Mediterranean to spawn—in Spain, the fishery is between April and June. The water turns red with blood as the tuna are brought in—if you’re faint-hearted, do skip the next movie.

The clip above shows the modern-day capture of tuna in Barbate, a town near Conil. A few centuries ago the fishery was so profitable that the Duke of Medina-Sidonia claimed the profits for himself after the conquest of Tarifa from the Moors. Tuna were and are still fished all over the Mediterranean—they even have a country named after them: it’s called Tunisia.

Since we’re doing movie-time, I felt it was essential to share the clip below with you—it was filmed in the early nineteen-sixties in the Algarve, southern Portugal. From the barefoot fishermen to the old women crocheting, it’s more than a fishing documentary—it’s a way of life.

The independence wars in Angola, Mozambique, and Portuguese Guinea had just erupted, young men were being conscripted to fight overseas, and Salazar’s dictatorship was in full swing.

I scuppered my trip east—I was targeting a tuna restaurant, but when I called them up, I found it was booked for weeks.

Of course you cannot go to a place like Sanlúcar without ending up in the fish market—so I did. It’s an unusual place, a medley of vegetable stalls, butchers, shops selling the local embutidos, and fishmongers.

The tuna stalls were opposite each other—one was empty, the other was mobbed. I waited patiently in line behind some restaurant buyers, and watched tuna, swordfish, and hake vanish rapidly.

Finally, it was my turn to get at the precious loot. Further on, I hit the gamba blanca stall, and stocked up on mantis along the way.

I kept meeting the same Andalucian woman at various stalls, sometimes behind me in the queue, others in front—inevitably, great mirth ensued, and she bombarded me with a barrage of Gaditano aspirated vowels.

In one stall, baby sole were for sale. Many years ago I saw the same thing in markets near Lisbon, described as ‘folhas de oliveira’, or olive leaves.

Lisbon and Sanlúcar have one thing in common—they sit next to the two greatest estuaries in Iberia, the Tagus and the Guadalquivir. And whenever you fish an estuary, there will be little fish for sale; estuaries are the most wonderful waterways in the world—a mix of salt and fresh waters, a place where mud meets sand, and a haven of shallow, murky water where baby fish come to grow.

Baby sole for sale at the fish market in Sanlúcar de Barrameda. If you look carefully, you’ll spot the mantis shrimp in the background.

But the most wonderful thing about these baby soles is their name—which of course I discussed with my new Andalucian friend, a mutual glint in our eyes, while the stallholder enviously looked on.

For these babies have a name which echoes all that we loathe about the politics and politicians that surround us. They’re called tapa culos—ass covers.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

 

 

The Fourth Root

July 28, 2018

Eighty people died in Greece over the last week. The Carr wildfire is consuming northern California—it ain’t just the girls that are warm there now!

Last year, Portugal burned up—sixty-six dead. 0n October 15th, 2017, four hundred and forty fires raged in western Iberia, thirty-three of which were sizable—another fifty victims.

Southern Europe. Australia. Western US. Gaia is speaking to us, and we’re not listening.

A graphic from the Washington Post showing our planet boiling up this summer.

The UK’s Daily Telegraph informs us about the rainfall figures in the southeast UK—in some cases, six percent of the normal June precipitation. But, it hastens to add:

The Met Office said there was no strong evidence linking the warmer and drier Junes of the last two years to the planet’s warming climate.

The Washington Post, however, tells us that scientists disagree—the climate is supercharging the weather. By climate, we’re talking about climate change, and out of the many interesting points made by the authors, this is the most important.

Gone are the days when scientists drew a bright line dividing weather and climate. Now researchers can examine a weather event and estimate how much climate change had to do with causing or exacerbating it.

In other words, climate scientists can tell you how much worse a particular weather event is because of the change in climate.

For wildfires, that’s not surprising—the closer you are to a flashpoint, the more likely the flash. Kevin Trenberth, who works at NCAR, uses the following analogy in his discussion of the consequences of even a modest heat build-up from global warming.

The accumulated energy over one month is equivalent to a small microwave oven at full power for six minutes over every square foot of the planet. No wonder things catch on fire.

The article in the Post discusses the proximal reason for Western Europe’s summer woes—the split jet pattern. Put simply, the jet stream is behaving badly.

Computer model forecast of the jetstream, produced by Netweather (netweather.tv)

The split jet pattern creates a barrier, rather than promoting airflow, and leads to prolonged weather system stagnation. The jet stream wind system, which is a balance between the trades and the roaring forties, was the mainstay of Atlantic navigation in the days of sail—it’s because of the jet stream that flying from North America to Europe takes less time than flying back.

The remarkable thing about all this is that citizens and societies are unable or unwilling to apportion blame. Just as in the loss of middle class jobs—the main theme for my forthcoming book, The Hourglass—here too we see corporations reaping the benefits, and governments and people paying the price.

In economics, these are known as negative externalities—someone picks up your shit. I did some math for my new book, and there’s no way that Universal Basic Income will compensate for substantial job losses due to artificial intelligence without a huge increase in government debt, while corporate profits soar. In a similar way, manufacturers who are profligate with greenhouse gas emissions make money while society pays the toll—not just in cash, but in blood.

But climate change needs to be considered as part of a larger problem—one that requires a holistic solution. From E.O. Wilson’s book, Half-Earth, I learned the acronym HIPPO: Habitat, Invasive Species, Pollution, Population, and Overexploitation (overhunting, overfishing…).

The book may prove a difficult vacation read, because Wilson cannot resist an excess of detail on Latin names and other biological esoterica—a shame because it will reduce the readership of this fascinating and terrible story.

Wilson discusses the present age—many call it the Anthropocene, a brave new world where Man manages a garden of species. The controversy rages. Ellis, who works at the University of Maryland, responded to an article in Wired with these words:

Nature is gone. It was gone before you were born, before your parents were born, before the pilgrims arrived, before the pyramids were built. You are living on a used planet. If this bothers you, get over it. We now live in the Anthropocene ― a geological epoch in which Earth’s atmosphere, lithosphere and biosphere are shaped primarily by human forces.

Emma Marris, a US journalist, writes:

Our true role as rulers of the planet is to turn its biodiversity into a global, half-wild rambunctious garden tended by us.

To which I say, “Bollocks!”

Ed Wilson prefers to call the coming age the Eremocene—the Age of Loneliness, where we have destroyed so much of the wondrous biodiversity that exists on the planet that we have very few friends to keep us company.

Ecologists have a rule of thumb for species extinction, based on observations in various ecosystems in different parts of the world. It is a simple rule: if you decrease available habitat, for instance by clear-cutting a tropical forest, you can calculate the corresponding loss in species. It’s done by taking the fourth root of what you have left.

If you destroy ninety percent of a forest, you’re left with about half the species, whereas if you destroy only ten percent, you get to keep ninety-seven percent of the species.

Wilson’s proposes that we leave half the earth unoccupied. If we choose to do so, and calculate the fourth root (sounds complex, but just type =SQRT(SQRT(0.5)) into Excel), the answer is eighty-four percent.

We get to leave the vast majority of other species alone, the ultimate gift for our children and their children, and a way to escape the age of loneliness.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

New Kid in Town

July 7, 2018

I start once more with a musical reference, and that gives me an excuse to recommend a book for your summer vacation. As you know, my initial motivation for writing a blog was to promote The India Road, but as happens both in books and reality, things took on a life of their own—it’s been a decade.

And, yes, my chronicles view history in the broadest possible way, both in terms of scope and scale—like ecology, history can focus on specifics (musical or culinary history, or the history of smart phones) and it can deal with a minute or a millennium.

It’s very unusual for you to find book recommendations here—other than my own—but I am suggesting you read Dream Boogie. Not only for the music, but because it is in many ways a history of the US civil rights struggle—Sam Cooke, like Mahalia Jackson, Ray Charles, Aretha Franklin and many others, made his mark in gospel music, which meant frequent tours of the American South.

I linked the analog version, since I don’t want you to think I’m dragging you to the dark side, but my Kindle version is abundantly hot-linked, and I’ve spent many a moment jumping to artists and songs I’d never heard ; this is truly what multimedia—a term more reminiscent of the Apple Mac hypercard stacks than of our brave new world—means.

The most amusing feature of this clip is the performance (aka antics) of Joe Walsh. A no-nonsense, kick-ass guitarist, you rarely see him on keys.

Now we’ve got a few things out of the way, let’s talk about the new kid on the block. Or if you prefer it in Russian, Novichok. It is apparently more common than menhirs in parts of southeast England.

The ‘newbie’, to directly transplant the Russian name, was developed in the last century, with the stated aim of circumventing the Chemical Weapons Treaty—signatory nations agreed to ban a specific set of weapons, as defined by their chemical formulas, and the immediate response (I certainly don’t think it was a Soviet exclusive) was to make meaner chemicals.

These required different formulas, exempting them from the CWT, but the Soviet ones also needed to penetrate NATO protective gear, and be apparently innocuous—no color, no smell, no taste—the perfect маскировка.

One subtle twist is that the development of Novichok agents was actually funded by the West, through a defense conversion fund offered to the USSR.

These nerve agents have re-surfaced over the poisoning of the Skripals in Salisbury, UK, and more recently of a local couple—the last footage before their collapse shows a man drinking a can of beer in the street while the woman buys (lots) more alcohol at a convenience store.

The Russians have strongly denied any involvement in the poisonings, although the manufacture of Novichoks (they’re a family of compounds, not one) by the USSR is well-established. To complicate matters, the British top-secret center for chemical and biological weapons at Porton Down is only five miles northeast of Salisbury, and the most recent poisoning happened in Amesbury, only a couple of miles from the secretive military facility.

The early XXth century nerve agents, such as mustard gas, relied on the toxic and highly reactive chlorine gas, but by 1936, Gerhard Schrader, a top-flight German chemist, had produced a phosphorus-based nerve gas called Tabon—by 1937, he had synthesized Sarin.

All these compounds work to inhibit transmission of nerve impulses at the synapse, by competing with a molecule called acetylcholine.

The connection between nerve fibers, or neurons, is where chemical weapons act.

The Nazis didn’t use chemical weapons—although they manufactured them—but their knowledge was not lost in the post-war arms race. Just as the US rocket science program cynically procured the man behind the V-2 bomb, Wernher von Braun, so too did Americans, Russians, and Brits enthusiastically endorse chemical weapons research—the nerve agent VX was discovered by Britain in the 1950s, and recently used to good effect on Kim Jong-Un’s half-brother at Kuala Lumpur airport.

All good clean fun, featuring the usual boys and their usual toys. And although it doesn’t bear thinking about, isn’t it just a touch weird that all this maychem (a surprisingly successful fusion of mayhem, featuring the UK prime minister and chemical weapons) occurred a stone’s throw from Porton Down?

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

 

Pot Luck

June 16, 2018

The plane’s tires squealed onto the runway at London’s Heathrow airport, leaving a trail of vaporized rubber, and I made a dash for the rental desk.

On paper, I only had a two hour drive ahead, but traffic on the M25 can easily double that—in the words of the immortal Yogi Berra, ‘in theory, theory is like practice, in practice, it isn’t.’ Or perhaps another Berra quote would be more appropriate: ‘When you get to a fork in the road, take it!’

After getting the hang of the brand-new BMW, I switched the radio onto LBC. I used to think the ‘L’ stood for London, and I speculated about the B & C, but the station self-promotes as ‘Leading Britain’s Conversation’—talk radio at a suitably silly level, with guest hosts like Salmond and Farage stirring the random bigotry of callers—just the sort of thing to while away a traditional Monday afternoon Brit traffic jam.

On my walk through the concourse I picked up the obligatory copy of Private Eye and lingered long enough to see that all the tabloid newspapers sported an identical cover, exhorting British members of parliament to be true to the people—a key brexit vote was underway.

LBC was split between the parliamentary story and a human interest piece on cannabis oil—the mother of an epileptic child was bringing back medical marijuana from Canada in the form of THC oil. The move was designed as a publicity stunt to promote the legal use of medical cannabis in the UK.

Her twelve-year-old was caught up in the middle of this, which seems a little unfair—epileptic fits are bad enough without extra publicity and invasion of privacy.

But the UK attitude to drugs has historically been extremely negative, even though drug use is widespread, so her majesty’s customs officers dutifully apprehended the hash oil, and a press conference followed, in which the mother dutifully explained she would simply return to Canada to buy more.

The British Home Office, in an effort to reduce the noise, dutifully released the offending dope to the offended parental later that day—by which time the traffic was flowing along quite nicely up the M40. By surrendering the oil, the story shifted to a non-story, and devolved to a background hum on legalization—political savvy, by contrast to the mayhem in the House of Commons.

It seems pretty clear that cannabis oil has medical benefits for some central nervous system disorders, of which epilepsy is the foremost candidate. In the UK, weed is a class B drug, which means a potential five-year imprisonment period and an unlimited fine—and as in every other country where such draconian measures exist, the punishment is in no way a deterrent.

Gone to pot? Trends in cannabis consumption in the UK.

The decreasing trend in dope-smoking appeared to halt in 2010, when the labour government bumped weed back into class B, i.e. making possession a crime punishable with imprisonment. The then-home secretary ignored the advice of her own senior scientific adviser, a professor with the delightful name of David Nutt.

The politician in question later resigned when it emerged she had filed an expense claim to pay for her husband’s adult films, and subsequently lost her parliamentary seat.

Medical marijuana is all the rage, partly because the word medical is increasingly optional, as various US states finally make it legal to smoke dope. The debate around oils, which are really just a chemical technique to concentrate the active substance, revolves around THC.

The alternative is CBD, the molecular sister of THC that doesn’t get you high. Cannabidiol, or CBD oil, is legal in many countries, and you can buy it online from UK suppliers—of course, in the Netherlands, you can also easily buy the THC variety.

Although the UK makes it very difficult for medicines containing THC oil to be sold, it is the largest producer and exporter of hash oil in the world. One of the LBC callers phoned in with this fun fact, and was quickly checked correct.

Various callers were quick to point out the irony and fumed at the double standard. I was a little perplexed, since Britain manufactures and exports all kinds of weapons, from armed personnel carriers to surface-to-air missiles—including the Bond-like Thunderbird—but you can’t buy them in Boots.

For many countries, it’s a case of ‘do as I say and not as I do’, a landmark parental strategy. But GW Pharmaceuticals produces ninety-five tonnes of ‘legal cannabis’ per year, according to the Daily Telegraph, almost half of the world supply. The word ‘legal’ just confuses things—GW, which lists on the NASDAQ as GWPH, markets Sativex, which contains THC, is prohibitively expensive, and not recognized by the UK National Health Service as cost-effective. In the Telegraph article, the aptly named Steve Rolles calls the paradox ‘profoundly unethical’—he’s right, but the double standard runs very deep, through weapons, alcohol, child labor, and other examples—and is by no means a British exclusive.

While the hash oil debate fizzled out, the Westminster vote also became a storm in a teacup. Theresa May survived yet another mutiny, and by the next afternoon, on my drive south, the nation’s preoccupation was all about exam stress—mothers complained bitterly that their kids were traumatized by the severity of Britain’s high school exams.

UK exams were always tough, but back in the day, a couple of medicinal tokes certainly eased the head—no exam question ever seemed threatening after being read out by Mr. C.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

 

Robocrop

June 9, 2018

Beautiful Eyes

Sandra Peck pushed the cart toward the deli counter.

Last stop before checkout.

She picked out some redskin potato salad, a packet of Italian sausage, and a tub of organic kale salad mix, patted Tyler on the head—she always marveled at the toddler’s beautiful blond curls—and aimed the cart toward the till.

Tyler was on his best behavior today, but unless the child was in meltdown mode, Sandy welcomed a little wailing—it was a welcome distraction as she rang up the groceries.

The supermarket was busy—not so much that she was crowded at the self-service till, but busy enough to distract the attendants.

Sandy had been through a bunch of jobs since dropping out of school, most of them service stuff. The second last was at a packing plant—the new machinery threw four workers into unemployment within three weeks—she got sixty-three dollars severance and a thank-you note.

Sandy’s last job, in one of the biggest supermarket chains, paid so poorly she’d been on food stamps. There, too, management was busy replacing the checkout operators with shiny aluminum contraptions equipped with screens, buttons, and balances.

When the store started doing away with the till operators, mostly young women like herself, replaced by the self-service option, her boss kept a few of the girls on to help customers—young people took to the machines immediately, thumbing away at the cellphone with one hand, ringing up groceries with the other.

Older people struggled. The sequence of instructions flashed on the screen seemed harder for them to understand—they peered at the scales and trays and gingerly tapped the touchscreen, waiting anxiously for things to happen. Some muttered to themselves.

One elderly gentleman was so bemused by the whole operation that Sandy had to step in with her master code and undo the last five things he’d done. Maybe she was a little impatient with him—Tyler was teething and yelled all night, and the queue behind Mr. Confused was backing up.

“Young lady, no need to snap at me!” the man said. He sneered. “Guess y’all love this machine that’s gonna put you out of work!”

Sure enough, she was fired at the end of the week.

Maybe the guy complained to the manager, Sandy thought as she began ringing up her items. Tyler reached out and tried to touch the screen. She played the stressed mother as she held back the toddler and worked through the produce.

She turned her back just so as she tapped the screen—she’d worked enough self-checkouts to know exactly what to do. She weighed the avocados. Then the mangoes, and finally the papayas. For each one, she tapped the same icon on the screen. Tyler cried and squirmed in her arms, straining for the buttons.

“Shush, honey. It’ll make your eyes pretty.” She smiled at the man behind her. “We’ll save the planet”—she read the words for the little boy as she picked up her eco-bag.

Perfect. Sandy smiled as she walked through the parking lot. She opened the trunk and let Tyler get in and climb over the back seat—the toddler shouted ‘Maamaaa’ as he rolled down the other side and clambered into the child seat, whooping with delight.

She closed the trunk, groceries safely stowed, fixed Tyler’s straps, started the clapped-out old Hyundai, the muffler sounding like a dragster on MDMA, and took the on-ramp to the 405.

“Hey Tyler, let’s go see Uncle Toby!” She turned up the radio, singing along with Taylor Swift—Shake It Up, with all the moves. The toddler was dancing in his chair. Momma smiled and hit the gas.

Sandra’s checking account didn’t stretch to luxury fruit items—avocado toast was fine for the Malibu set, but it was way above her pay grade. She’d unload all that—Toby would add it to his supply and sell it at the farmer’s market after a little organic relabeling.

What she got from the fruit vendor would be enough to pay her whole grocery bill. As for the produce, good job she’d only paid for carrots.

The shiny robot self-checkout that sells more carrots than were ever stocked by the store.

Epilogue

By 2019 there will be an estimated three hundred and twenty-five thousand self-checkouts on the planet—at the rate such things grow, we can expect half a million by the third decade of the new millennium. I’m not sure what this century will be famous for, and most of us won’t live it out, but right now it’s the century of consumer automation.

In five years or so, supermarkets will have put half a million people out of work. At minimum wage of 5-10 bucks an hour, we’re talking savings of one hundred and fifty million bucks per week—five to ten billion dollars per year.

One Australian supermarket recently discovered that its customers had become extremely health-conscious—one shopper alone had purchased forty pounds of carrots—makes for beautiful eyes.

Sadly, when the supermarket looked more closely at the issue, it found out it had sold more carrots than its entire supply. As robots take over human jobs, humans have less money. But they also have more time on their hands to machinate and plot their revenge. After all, when man discovered fire, he promptly burned his neighbor.

There’s a new game in town, and it’s called ‘cheat the robot.’

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

 

Invisible

April 21, 2018

It’s a hot night in Sukhumvit. Muggy, too. Ninety degrees with seventy percent humidity is an oppressive atmosphere—after a few minutes, a light rain begins to fall.

Bangkok is gearing up for the evening as I climb the walkway stairs onto the pedestrian bridge. The road is twelve feet below me, and I look down at the traffic— bumper to bumper chaos across all six lanes.

It’s strangely light on the footpath, because of the flashing neon and the glaring headlights below. At the north end of the walkway, I spot a small figure moving around, a moth caught in a flame.

The dark end of the street. A child plays alone over a busy Bangkok thoroughfare.

The little girl is perhaps three years old—she may be older, because malnutrition is rife in this part of the world. She jumps over the other three kids, holds the railings, and starts to rummage inside a plastic bag.

Everyone else is exhausted, and her mother is the very image of hopelessness. I imagine the child perched on the handrail, slipping and falling onto the traffic while the whole family sleeps.

I should do a hundred things, but all I do is take this picture. I feel shitty, helpless, and desperate. I think of the family now, as I write these words. It’s early evening in southeast Asia, and this infant will be settling down for the night on the footbridge.

Is she still alive today? Who knows! What brings a mother to such utter exhaustion that she can sleep, comatose against the hard steel railing, while her child dabbles with death? Where’s the father?

Every year, every day, mountains of people die in developing nations, and no one knows why. Children, adolescents, they just vanish. The families mourn, life moves on.

I’m not talking of kidnapping, or kids who run away—they vanish in the sense that one moment they’re alive, and the next they’re dead. In the West, we have a far better grip on health care, despite our constant gripes—if a child is ill, shows symptoms of illness, there is a safety net.

In much of SE Asia, in most of Africa, there’s no net. Take me back five centuries to medieval Europe, and that’s where they are today.

Maybe you think mountain is a poor choice of words. The WHO estimates 5.6 million children die every year before their fifth birthday—the cause of death is known only for three percent. Where does this happen? You guessed it—mainly Africa and south Asia.

How would it sit with Western nations if ninety-seven percent of deaths for the under-fives in France, California, or Ontario went unexplained?

More desperately, a lot of kids who die in faraway countries were never born in the first place—legally, that is. So there’s no traceability—no one knows you were born, no one notices you vanished.

Shame, shame, shame, as the West discusses Trump’s salacious stormy snafus, or the innards of When Harry Met Meghan.

The Bill and Melinda Gates Foundation’s CHAMPS project includes research on MITS—Minimally Invasive Tissue Sampling, a way to quickly determine cause of death with high accuracy.

Humans are like ecosystems—you can know their health based on what goes in, what’s inside, or what comes out. Pee is one of the best indicators—doctors have used it for four thousand years. In Shakespeare’s Henry IV, urine’s praises are sung by the bard.

FALSTAFF

Sirrah, you giant, what says the doctor to my water?

Page

He said, sir, the water itself was a good healthy
water; but, for the party that owed it, he might
have more diseases than he knew for.

Nowadays, a medic is no longer forced to sip your piss to diagnose diabetes, but run-of-the-mill blood and urine tests are not so many decades old. In CHAMPS, doctors extract tissue samples from brain, lungs, and liver. Add a little blood and spinal fluid, and throw the power of biomedical analysis at the ensemble.

The extraction itself takes under half an hour, and a non-specialist can easily be trained to do it. In some of the poorest countries in the world, home to many of these ‘Invisibles’, cutting-edge techniques are helping to bring a little closure to grieving families.

In Mozambique, the seventh poorest country in the world, public health is a dire problem—the nation is mired in environmental quality issues, poor medical services, and the twin evils of superstition and witch doctors.

In many communities, relatives will not allow a corpse to be autopsied—the reasons may be cultural or religious, but in a number of African countries, organ theft is a reality, so opening a body is simply taboo.

A biopsy needle leaves no traces, but perhaps the world can begin to have a little more traceability. By knowing why so many small children die, maybe we can start to care more about things that really matter.

And every time a kid plays on the railings above a crowded street, every person should at least have the courage to ask why.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.

 

Chrysopoeia

March 3, 2018

Science was once an insular sport. Scientists were viewed as eccentrics, possibly madmen, who performed all sorts of bizarre experiments, paced the countryside observing its flora, fauna, or geology, collected specimens, and scribbled furiously in notebooks.

Many of those laboratory trials were in fact rather strange, right back to the days of the alchemists and the philosopher’s stone. The attraction of mercury, due to its odd properties, probably concealed its deadly nature. A good many scientists of that era probably went slowly crazy due to mercury’s effects on the central nervous system, which may have compounded the oddity of their experimental protocols.

Before the XIXth century, researchers in different European nations were mostly unaware of each others’ work. It must have been a moment of great excitement when any of them found a kindred spirit—these were men driven by ideas, for whom the very notion of an intellectual battle was high jinx.

Scientists throughout the world continue to treasure intellectual jousting, but the discussion of concepts, methods, and results is played on two altogether different stages—conferences and academic journals.

The oldest ‘science club’ in the world is the U.K.’s Royal Society, founded in 1660. There, the most eminent thinkers met and discussed their theoretical and practical research. Other societies were created in France, Germany, and elsewhere, and discussions began to flourish—a legendary exchange took place in Oxford in 1860, when Bishop Wilberforce asked T.H. Huxley whether it was ”through his grandfather or his grandmother that he claimed his descent from a monkey.’

Huxley, in his defense of Darwinism, replied:

I would not be ashamed to have a monkey for an ancestor; but I would be ashamed to be connected with a man who used great gifts to obscure the truth.

The step from the spoken to the written word began when members began writing letters to their society’s president—these letters were the precursors of today’s journal articles.

It became standard practice to send such letters out for comment to a Fellow’s peers—in other words, this was the start of the scientific peer review process. In time, the approved letters turned into publications—today’s academic journals. The entire process of peer review was considered an obligation for scientists and academics throughout the world—a duty to be performed free of charge.

What has changed is the nature of the organizations that publish scientific papers. Throughout the XXth century, scientific societies mushroomed, with each subject area creating its own association, often country by country—and as different academic institutions began requiring that their staff publish journal papers in order to demonstrate their scientific capacity, science publication became big business.

With the advent of digital journals, the field boomed. No longer was it necessary to build, staff, and maintain huge, ivy-walled libraries, the ex-libris of Harvard, Oxford, or Bologna—the only requirement was a server farm. And along with the reduction in production costs came consolidation.

Nature and Science are the truly elite journals, but a huge set of upper- and mid-level journals are in the hands of a small group of publishers: the Dutch giant Elsevier—itself a child of behemoth Reed-Elsevier, the German colossus Springer, and a few others.

But one thing did not change—the free work that academics perform for the editorial conglomerates. This is now a system that can be safely qualified as abusive—no longer is this a set of dedicated intellectuals working on all four sides, i.e. writing, reviewing, publishing, and reading, but a money-making behemoth exploiting the good will of the academic community.

ScienceDirect, the flagship Elsevier website, contains a mere 12.5 million papers, from three thousand five hundred academic journals, along with thirty-four thousand e-books.

Each year, Elsevier publishes two hundred and fifty thousand articles, and interestingly, ‘a small minority‘ are apparently fake. One comment on the ‘minority’ states that for a scientist, that might be one percent, which suggests that out of the total repository, perhaps one hundred twenty-five thousand papers are fake news—even more interesting is one of the ways this deception is performed—since journal editors ask would-be authors for suggestions of reviewer names, some authors provide fake email addresses for their lists.

Since each one of these 250,000 articles is typically reviewed for free by three scientists, and probably takes about three hours to review, we are talking about two million person-hours per year. At about thirty dollars an hour, that’s a saving of sixty million bucks a year—multiply that by four or five majors, and we’re talking well over two hundred and fifty million bucks saved.

Maybe that’s chrysopoeia, the philosopher’s stone—turning quicksilver intellect into solid gold cash.

The India Road, Atmos Fear, Clear Eyes, and Folk Tales For Future Dreamers. QR links for smartphones and tablets.


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